Are you experiencing shooting pain throughout your hands and feet? Does the pain range between stabbing, shooting, numbing, and tingling sensations? If you think this is confusing, imagine what state the nerve fibers within our bodies are in. These sensations result from damaged nerve fibers sending false signals to our pain centers. When persistent, the accompanying sensations are said to worsen over time, wreaking physical and mental havoc.
Dubbed neuropathic pain, this condition is deemed a combination of several others, mostly starting in the central nervous system. How does one go about easing said symptoms? One team claims to have developed a supplement that targets the root cause, and so far, the angle looks like a promising one. This is where it is fitting to introduce ProNerve6.
What is ProNerve6?
ProNerve6 is a nerve health supplement believed to target the root cause of neuropathic pain. This all-natural and simple formula targets a group of cells in the brain. Like our immune system, this group is critical in fighting and warding off harmful invaders. As in the former case, persistent activation of a defense system sometimes leads to turning against the good as opposed to the bad, increasing inflammation and the risk of developing neurodegenerative and nerve-related conditions.
When taken as directed, ProNerve6 is trusted to go beyond lowering inflammation; it might strengthen the overall integrity of our nerves and improve blood circulation (critical for neuronal and cellular communication, recovery, and regrowth). For a complete picture of ProNerve6, let’s go over its underlying mechanism.
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How does ProNerve6 work?
ProNerve6 targets a group of cells called microglia. One study defines microglia as a neuronal support cell in the central nervous system (CNS). They act as the first line of defense for our immune system in the CNS. This means scavenging the CNS for plaques, damaged neurons, and other aspects that might harm normal brain functions. Naturally, microglia activation is important to keep invading pathogens away; however, the issue arises when such activation persists or is sustained over time.
Researchers believe that the latter gives rise to poor neuronal plasticity, impairs memory, and might be a driving force for neurodegenerative diseases. The reason for this is the increased release of inflammatory cytokines (TNA-alpha, IL-6, IL-1-beta, reactive oxygen species, etc.), which simultaneously forces microglia to exhibit neuroprotective and detrimental effects, causing more harm than good. Upon activation, this particular group of cells might also contribute to sensory and/or non-sensory aspects of neuropathic pain.
Neuropathic pain is described as pain caused by a lesion in the somatosensory nervous system. In other words, it is a maladaptive response to an injury in the nervous system. Interestingly, microglia control certain brain and spinal regions, which might explain the shooting of pain down the neck, lower back, and leg, among others. One team of researchers noted that “microglia participate in the onset, maintenance, mediation, and expansion of neuropathic pain,” further noting that nerve damage contributes to microglia activation.
In light of everything, the creators of ProNerve6 formulated this supplement to try to turn off the microglia switch so that it isn’t in constant activation mode. This is probably a good time to navigate the ingredient list.
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What are the key ingredients inside ProNerve6?
The main ingredients inside ProNerve6 are:
Biletan
Biletan (more commonly known as alpha-lipoic acid) is a vitamin-like antioxidant that reportedly passes the blood-brain barrier to detoxify brain cells of toxins. In terms of neuropathy, this ingredient has been shown to ease the symptoms of diabetic neuropathy, which is a type of nerve damage brought on by diabetes. For those who aren’t familiar with this nerve damage, it is known for causing pain and tingling in the hands and feet, as well as increasing loss of feeling, deteriorating digestive function, and lowering sexual function.
As an antioxidant, biletan might counteract harmful invaders (i.e., free radicals) linked to increased oxidative stress, leading to inflammation. A 2019 study that looked at the effects of biletan on microglia cells reported significant attenuation, namely in pro-inflammatory cytokines such as TNF-alpha and IL-6, among others, thereby easing the neuroinflammatory response.
Baicalin
Baicalin is a flavonoid antioxidant found in American and Chinese skullcap plants, best known for its antioxidant, anti-inflammatory, antiviral, and antibacterial properties. These properties allow the compound to improve mood, reduce inflammation, and possibly exhibit anticancer effects. In the context of reducing inflammation, this doesn’t come as a surprise, as antioxidants help neutralize free radicals, which, as discussed earlier, is critical for lowering oxidative stress.
A study that looked at the effects of baicalin on cognitive impairment and neuronal protection against microglia-induced neuroinflammation arrived at promising results. In particular, the researchers found that taking baicalin helped ease symptoms of spatial memory dysfunction and decreased the number of activated microglia, pro-inflammatory cytokines, and neuroinflammation-induced neuron death in mice. These results led them to conclude that baicalin might be a promising neuroprotective compound.
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Diferuloylmethane
Diferuloylmethane (curcumin) is a bioactive compound extracted from the Indian spice turmeric. This ingredient has garnered much attention for its anti-inflammatory, antioxidant, antimicrobial, immunomodulatory, and anti-tumor effects. So far, studies have provided promising evidence regarding curcumin’s protective abilities in the context of neuroinflammation. Specifically, it can potentially alleviate conditions brought on by viral infections, atherosclerosis, intracerebral hemorrhage, and neurodegenerative diseases caused by microglia.
In the brain, this compound might prevent “microglial transformation,” adding that it is equally suitable for modulating inflammatory mediators. As for the exact mechanism by which these results are attained, curcumin is believed to block the NF-kb pathway, which reduces proinflammatory markers and TLR-4 activation (a signaling pathway linked to inflammation).
Acetyl-L-carnitine
Acetyl-l-carnitine (ALCAR) is an acetylated form of the l-carnitine amino acid, available through supplementation and naturally throughout the human body. Regardless of the source, this ingredient is critical in increasing energy production (transporting fatty acids to the cells’ powerhouse). Of the different forms available, ALCAR is the only one deemed effective for the brain. In particular, it has been proven (to some extent) to prevent age-related mental decline and improve one’s ability to learn new information.
Moreover, it might improve the overall cognition of people with dementia. Concerning neuroprotection, this ingredient might improve energy status, decrease oxidative stress, prevent cellular death, and improve levels of key neurotransmitters associated with healthy mood (e.g., glutamate, glutamine, and GABA, among others). Not to mention its role in increasing myelination (a shield for our nerves) and cell growth.
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Frequently Asked Questions (FAQ)
Q. Who is ProNerve6 suitable for?
A. ProNerve6 is suitable for anyone who is suffering from any nerve-related pain. In particular, the creators encourage those who have lost sleep over nerve issues, whether in the feet or legs, and felt limited in their range of movement when stretching, walking, or cleaning the house to give ProNerve6 a try. At the time of writing, this formula was trusted to work regardless of age and gender.
Q. What features does ProNerve6 have?
A. ProNerve6 is an all-natural supplement that is also antibiotic-free, sugar-free, hormone-free, gluten-free, and lactose-free.
Q. Is ProNerve6 safe?
A. Based on our research of the ingredients, ProNerve6 includes many ingredients that are already readily available in dietary supplements and have promising evidence when it comes to deactivating microglia. Alas, the creators have yet to disclose the concentration of the proprietary blend or each ingredient individually to confirm safety or effectiveness at the time of writing. This is something that needs to be taken up with the customer support team.
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Q. Can I take ProNerve6 with other prescription medications?
A. Since the creators of ProNerve6 do not have the authority to provide individualized medical advice, individuals are accountable for doing their due diligence before getting started. A good first step would be to review the ingredients and see whether they might influence a prescription medication currently being taken. If things are still unclear, consulting a healthcare provider is the only way to approach this.
Q. How should I take ProNerve6?
A. One ProNerve6 serving size consists of two capsules. Since each bottle includes 60 capsules, individuals might have to take a serving daily to notice improvements in their pain sources.
Q. What are the reported benefits of taking ProNerve6?
A. When taken as directed, ProNerve6 might help reduce inflammation, restore nerve integrity, and improve blood circulation. Other areas of health that might improve due to rectifying nerve health include better digestion, energy levels, improved sleep quality, and mental health.
Q. What is the estimated arrival time for ProNerve6 shipments?
A. On average, ProNerve6 shipments within the contingent United States should take 5 to 7 business days. Otherwise, depending on the location to which these supplements are being shipped, the wait time can easily exceed ten business days.
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Q. Does A money-back guarantee protect ProNerve6 Purchases?
A. Yes, ProNerve6 is protected by a 180-day money-back guarantee. If, within the first 180 days of taking this supplement, individuals still experience a tingling sensation in their hands and feet or any stabbing or shooting pain throughout the body, then customer support can be reached for a full purchase price refund on all other unused ProNerve6 bottles. For the specifics of the refund policy, consider the contact information below:
- Email: support@pronerve6today.com
- Phone: 1 (732) 917-7670
How much does ProNerve6 cost?
Each ProNerve6 bottle includes 60 capsules to be split across a month. The creators recommend long-term use since deactivating microglia takes time, especially in people whose switch has been on for some time. To facilitate this, they are offering three different price points:
- 1 ProNerve6 bottle: $69 each + $9.95 in S&H
- 3 ProNerve6 bottles: $59 each + free U.S. S&H
- 6 ProNerve6 bottles: $49 each + free U.S. S&H
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For orders of 3 or 6 ProNerve6 bottles, individuals will also receive direct access to the following bonuses:
Bonus #1: Ancient Superfoods
In the first bonus, the creators of ProNerve6 will walk everyone through many superfoods they believe are ideal to take with the supplement. These aim to lower blood pressure and inflammation and reduce cancer risk. In addition to revealing the most nutritious kinds, the creators will go at length into their different properties, making this guide both hands-on and theoretical.
Bonus #2: Healthy Blood Sugar Protocol
In the second bonus, the creators spend considerable time reviewing the ins and outs of diabetic neuropathy. This actionable plan is intended to help people manage their blood sugar levels, especially those with type II diabetes. Some tips and tricks that people can expect from this bonus revolve around meals, snacking, beverages, and restaurant eating guidelines.
ProNerve6 is a dietary supplement aiming to turn off the microglia switch. As in the case of the immune system, if microglia cells remain activated for some time, their presence increases oxidative stress and pro-inflammatory markers while damaging neurons and the central nervous system. These cells impact the brain and the spine, and the main source of pain signals travel to other parts of the body, such as the hands and feet. Our research on the ingredients, which appears to be no more than four as this is being written, is quite promising.
Every ingredient targets microglia cells directly (decreasing their numbers) or attenuates associated consequences (i.e., lowering inflammatory markers, easing neuroinflammatory responses, etc.). As promising as these results are, individuals must remember that this angle is still being researched. Many available studies are based on lab experiments or animal studies. This is not to say that ProNerve6 won’t work; it is more a question of whether similar results can be replicated in human studies.
Alas, we cannot deny or confirm the results. However, the approach is comforting. The other downfall is the unavailability of a supplement’s facts. The creators have yet to disclose whether each ingredient is available independently or as a proprietary blend. If it is a proprietary blend, it will be difficult to decipher which ingredient outcomes are likely attributed to. But we can judge safety to a certain degree.
So far, the idea for ProNerve6 is interesting and may benefit users (not to forget the bonus resources as well). If not, at least each purchase is protected by a money-back guarantee. Before getting started, we encourage individuals to dig further into matters.
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